Multiple myeloma is a plasma cell dyscrasias that often complicating with neurological symptoms. Among these vertebral fractures, spinal canal compromises and peripheral neuropathies are best known. In this report, we present a case which peripheral neuropathy precedes acute paraparesis that is seen very rarely. A 58-year-old woman was admitted to our hospital with fatigue, nonspecific back pain and numbness in her legs. During hospitalisation she was treated for peripheral neuropathy that acute paraparesis was developed later on. Urgent lumbar magnetic resonance imaging showed an epidural mass that excised totally via dorsal midline approach. Pathology confirmed the diagnosis of plasmacytoma. Patient was able to mobilize independently one month after discharge.

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