Tricyclic antidepressants protect their importance among the emergency department visits. Amitryptiline, one of the tricyclic antidepressants, shows its effects by inhibiting the reuptake of epinephrine and serotonin from the adrenergic and serotonergic neurons by membrane pump inhibition. Performing its toxic effects on heart by using a similar mechanism with quinidine, amitriptyline slows down the intraventricular conduction through the inhibition of fast sodium channels on His bundle and Purkinje fibers. As a result, it is known that the drug causes primarily the QRS prolongation and also PR and QT prolongation, multifocal ventricular premature beat, ventricular tachycardia and fibrillation. Herein we report a case of suicide attempt which has T negativity as electrocardiographic (ECG) change caused by amitriptyline intoxication.

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