Epilepsy surgery is a therapeutic intervention for patients with medically refractory seizures. Anesthetic considerations epilepsy surgery for refractory epilepsy include ensuring a safe and comfortable perioperative experience for the patient, providing suitable operating conditions for the neurosurgeon, avoiding interference with intraoperative neuromonitoring recordings. Providing the conditions that simultaneously meet these requirements, using general anesthesia remains a significant challenge for the neuroanesthesiologist. The role of anesthesiologist acquires significant dimensions in management of epilepsy ranging from operative procedure, to the intensive care management of patients with status epilepticus. The knowledge regarding various antiepileptic agents and their potential side effects and interactions with anesthetic agents are of prime concern during surgical procedures for epilepsy. It requires a skilful and clinically precise handling of such patients during perioperative period by the all team, which is structured by anesthesiologist, neurosurgeon and neurologist. In this study, we aimed to discuss our standardized anesthesia protocol and review of the literaturefor epilepsy surgery.