Background:

The purpose of this study was to evaluate the effect of intraarticular injections(high and low molecular weight Hyaluronic Acid, NSAID) in patients with mild-to-moderate knee osteoarthritis.

Patients and Methods:

One hundred twenty patients (34 men, 86 women; mean age 56.55 years; range 40 to 78 years) who were primary knee osteoarthritis of Kellgren-Lawrence grade II-III, divided four groups consisting of randomly. High molecular weight hyaluronic acid content was administered intraarticularly to patients in Group–I, Low molecular weight hyaluronic acid content was administered intraarticularly to patients in Group–II, Group-III were administered Tenoxicam intraarticularly and 0.9 % saline were given to the fourth group as a control group. WOMAC Pain Scale values were applied to patients before treatment and after 3. month treatment. Student's t-test was used in statistical analysis of the data.

Results:

We have found statistically significant difference between the data picked before and after the treatment between administration of high and low moleculer weight hyaluronic acid.

Conclusion:

Intra-articular HA injections provide additional short-term benefits, but this therapy should be justified by further controlled studies with longer follow-up and larger patient groups.

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