Introduction:

Helicobacter pylori cause chronic inflammation. Mean platelet volume (MPV) is suggested to be a marker of inflammation including chronic inflammation. We aimed to evaluate any relation with Helicobacter pylori gastritis and MPV levels among children with Helicobacter pylori gastritis in this study.

Materials and Methods:

This retrospective observational study was conducted at two center: Afyon Kocatepe University Faculty of Medicine (Afyonkarahisar) and Yeditepe University Faculty of Medicine (Istanbul). The patients were divided into three groups; Group 1 (patients having Helicobacter pylori positive gastritis), group 2 (patients having gastritis but Helicobacter pylori negative), and group 3 (control group). Helicobacter pylori gastritis was diagnosed by histologic examination of endoscopic material, and one of either urea breath test or immunochromatographic stool test is positive. MPV levels of cases in each group were obtained from The Sysmex- XE 2000i automated blood cell analyzer.

Results:

The mean MPV values in group 1, group 2 and group 3 were 9.9±0.7, 10.5±0.7, and 9.8±0.9 fL, respectively. According to MPV values, there was statistically significant difference between group 1 and other groups; mean MPV levels of group 1 were smaller than group 2 and group 3; mean MPV levels of group 3 were smaller than group 2 (p<0.05). There was no correlation between MPV and histopathological parameters including inflammation, Helicobacter pylori density and activity.

Conclusion:

We suggest that Helicobacter pylori gastritis causes an inflammatory response, however, does not affects MPV levels among children.

Keywords: