Paralel to the development of new anesthetics, and advanced technological changes, anesthesia is being more safer for the patients. At the same time, surgical procedures are becoming longer and much more complex. Awake craniotomy is the technique of choice for certain neurosurgical procedures, including excision of lesions from eloquent cortical areas and procedures for epilepsy and movement disorders. The anesthesiologist should be maintain patient comfort, analgesia, immobility and cooperation adequately during the awake craniotomy. Due to extensive and effective use of modern aneasthetic methods, its indications are getting less. In this study we aimed to give our standardized anesthetic protocol for awake craniotomy and review of the literature.